General Information

  • ID:  hor006509
  • Uniprot ID:  Q9YGH5
  • Protein name:  Somatostatin-26
  • Gene name:  sst1a
  • Organism:  Carassius auratus (Goldfish)
  • Family:  Somatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AAGPMLAPRERKAGCKNFFWKTFTSC
  • Length:  26(89-114)
  • Propeptide:  MLSTRIQCALALLSLALAVCSVSAAPTDAKLRQLLQRSLLNPAGKQELARYTLADLLSELVQAENEALEPEDLSRAVEKDEVRLELERAAGPMLAPRERKAGCKNFFWKTFTSC
  • Signal peptide:  MLSTRIQCALALLSLALAVCSVSA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  15-26
  • Structure ID:  AF-Q9YGH5-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006509_AF2.pdbhor006509_ESM.pdb

Physical Information

Mass: 336454 Formula: C131H201N37O33S3
Absent amino acids: DHIQVY Common amino acids: A
pI: 10.51 Basic residues: 5
Polar residues: 8 Hydrophobic residues: 9
Hydrophobicity: -32.69 Boman Index: -3826
Half-Life / Aliphatic Index: 4.4 hour Aliphatic Index: 30.38
Instability Index: 2272.69 Extinction Coefficient cystines: 5625
Absorbance 280nm: 225

Literature

  • PubMed ID:  9827009
  • Title:  Evolution of neuroendocrine peptide systems: gonadotropin-releasing hormone and somatostatin.